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Not compatible

Does 16GB DDR5 (2x8GB) work with the B450?

No — not compatible: 16GB DDR5 (2x8GB) with B450. Memory mismatch: DDR5 RAM in a DDR4-only board. Live eBay prices.

How they line up

Spec
B450 B450
16GB DDR5 (2x8GB) 16GB DDR5 (2x8GB)
Socket
AM4
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Memory
DDR4
DDR5
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16GB DDR5 (2x8GB)
B450

Common questions

Memory mismatch: DDR5 RAM in a DDR4-only board.