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Not compatible

Does 16GB DDR4 (2x8GB) work with the B650E?

No — not compatible: 16GB DDR4 (2x8GB) with B650E. Memory mismatch: DDR4 RAM in a DDR5-only board. Live eBay prices.

How they line up

Spec
B650E B650E
16GB DDR4 (2x8GB) 16GB DDR4 (2x8GB)
Socket
AM5
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Memory
DDR5
DDR4
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16GB DDR4 (2x8GB)
B650E

Common questions

Memory mismatch: DDR4 RAM in a DDR5-only board.