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Not compatible

Does 64GB DDR5 (2x32GB) work with the B550?

No — not compatible: 64GB DDR5 (2x32GB) with B550. Memory mismatch: DDR5 RAM in a DDR4-only board. Live eBay prices.

How they line up

Spec
B550 B550
64GB DDR5 (2x32GB) 64GB DDR5 (2x32GB)
Socket
AM4
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Memory
DDR4
DDR5
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64GB DDR5 (2x32GB)
B550

Common questions

Memory mismatch: DDR5 RAM in a DDR4-only board.