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Not compatible

Does 16GB DDR5 (1x16GB) work with the X570?

No — not compatible: 16GB DDR5 (1x16GB) with X570. Memory mismatch: DDR5 RAM in a DDR4-only board. Live eBay prices.

How they line up

Spec
X570 X570
16GB DDR5 (1x16GB) 16GB DDR5 (1x16GB)
Socket
AM4
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Memory
DDR4
DDR5
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16GB DDR5 (1x16GB)
X570

Common questions

Memory mismatch: DDR5 RAM in a DDR4-only board.